A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies

Background: To determine the maximum tolerated dose (MTD), safety, potential pharmacokinetic (PK) interactions, and effect on liver histology of trabectedin in combination with pegylated liposomal doxorubicin (PLD) for advanced malignancies. Patients and methods: Entry criteria for the 36 patients i...

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Bibliografiske detaljer
Main Authors: von Mehren, M., Schilder, R. J., Cheng, J. D., Temmer, E., Cardoso, T. M., Renshaw, F. G., Bayever, E., Zannikos, P., Yuan, Z., Cohen, R. B.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2008
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2598415/
https://ncbi.nlm.nih.gov/pubmed/18497430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdn363
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