Phase I study of the safety and pharmacokinetics of trabectedin with docetaxel in patients with advanced malignancies

PURPOSE: Combination therapy with trabectedin and docetaxel was evaluated in patients with advanced malignancies. METHODS: In this open-label phase 1 study, docetaxel (60 or 75 mg/m(2); 1-h intravenous infusion) was given on day 1 of a 21-day cycle in combination with escalating doses of trabectedin...

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Gepubliceerd in:Cancer Chemother Pharmacol
Hoofdauteurs: von Mehren, Margaret, Bookman, Michael, Meropol, Neal J., Weiner, Louis M., Sherman, Eric, Li, Jinhui, Knoblauch, Roland, Parekh, Trilok, Cohen, Roger B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978949/
https://ncbi.nlm.nih.gov/pubmed/25791363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2705-z
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