A PHASE 1 STUDY OF GEMCITABINE COMBINED WITH DASATINIB IN PATIENTS WITH ADVANCED SOLID TUMORS

PURPOSE: Dasatinib has been shown preclinically to overcome resistance to gemcitabine. We evaluated the safety and biological activity of the combination of dasatinib and gemcitabine in patients with advanced solid tumors. EXPERIMENTAL DESIGN: In a phase 1 study (3+3 design), patients received daily...

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Veröffentlicht in:Invest New Drugs
Hauptverfasser: Hong, David S., Choe, Jennifer Hsing, Naing, Aung, Wheler, Jennifer J., Falchook, Gerald S., Piha-Paul, Sarina, Moulder, Stacy L., George, Goldy C., Choe, Jonathan M., Strauss, Lewis C., Gallick, Gary E., Kurzrock, Razelle
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482128/
https://ncbi.nlm.nih.gov/pubmed/23179336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9898-3
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