Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

BACKGROUND: Atopic dermatitis (AD; eczema) is characterized by a widespread abnormality in cutaneous barrier function and propensity to inflammation. Filaggrin is a multifunctional protein and plays a key role in skin barrier formation. Loss-of-function mutations in the gene encoding filaggrin (FLG)...

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Main Authors: Cole, Christian, Kroboth, Karin, Schurch, Nicholas J., Sandilands, Aileen, Sherstnev, Alexander, O'Regan, Grainne M., Watson, Rosemarie M., Irwin McLean, W.H., Barton, Geoffrey J., Irvine, Alan D., Brown, Sara J.
Format: Artigo
Language:Inglês
Published: Mosby 2014
Subjects:
Atopic Dermatitis and Skin Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090750/
https://ncbi.nlm.nih.gov/pubmed/24880632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.04.021
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