Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency

BACKGROUND: Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH. Because higher pH activates SC protease activity, we hypothesized an enhanced release of proinflammatory IL-1 cytokines from corneocytes in patien...

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Hoofdauteurs: Kezic, Sanja, O’Regan, Gráinne M., Lutter, René, Jakasa, Ivone, Koster, Ellen S., Saunders, Sean, Caspers, Peter, Kemperman, Patrick M.J.H., Puppels, Gerwin J., Sandilands, Aileen, Chen, Huijia, Campbell, Linda E., Kroboth, Karin, Watson, Rosemarie, Fallon, Padraic G., McLean, W. H. Irwin, Irvine, Alan D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Mosby 2012
Onderwerpen:
Atopic Dermatitis and Skin Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627959/
https://ncbi.nlm.nih.gov/pubmed/22322004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2011.12.989
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