Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

BACKGROUND: Filaggrin, coded by FLG, is the main source of several major components of natural moisturizing factor (NMF) in the stratum corneum (SC), including pyrrolidone carboxylic acid (PCA) and urocanic acid (UCA). Loss-offunction mutations in FLG lead to reduced levels of filaggrin degradation...

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Detalhes bibliográficos
Main Authors: Kezic, S, O’Regan, G M, Yau, N, Sandilands, A, Chen, H, Campbell, L E, Kroboth, K, Watson, R, Rowland, M, Irwin McLean, W H, Irvine, A D
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586662/
https://ncbi.nlm.nih.gov/pubmed/21261659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1398-9995.2010.02540.x
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