The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase γ

Mitochondrial DNA (mtDNA) mutations may contribute to aging and age-related diseases. Previously, we reported that accumulation of mtDNA mutations is associated with age-related hearing loss in mice carrying a mutator allele of the mitochondrial Polg DNA polymerase. To elucidate the role of mtDNA mu...

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Bibliographic Details
Main Authors: Someya, Shinichi, Yamasoba, Tatsuya, Kujoth, Gregory C., Pugh, Thomas D., Weindruch, Richard, Tanokura, Masaru, Prolla, Tomas A.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090612/
https://ncbi.nlm.nih.gov/pubmed/17363114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.01.014
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