PTEN C-terminal Deletion Causes Genomic Instability and Tumor Development

Tumor suppressor PTEN controls genomic stability and inhibits tumorigenesis. The N-terminal phosphatase domain of PTEN antagonizes the PI3K/AKT pathway, but its C-terminal function is less defined. Here we describe a knock-in mouse model of a nonsense mutation that results in deletion of the entire...

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Main Authors: Sun, Zhuo, Huang, Chuanxin, He, Jinxue, Lamb, Kristy L., Kang, Xi, Gu, Tingting, Shen, Wen Hong, Yin, Yuxin
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090077/
https://ncbi.nlm.nih.gov/pubmed/24561254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.030
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