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PTEN C-terminal Deletion Causes Genomic Instability and Tumor Development
Tumor suppressor PTEN controls genomic stability and inhibits tumorigenesis. The N-terminal phosphatase domain of PTEN antagonizes the PI3K/AKT pathway, but its C-terminal function is less defined. Here we describe a knock-in mouse model of a nonsense mutation that results in deletion of the entire...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4090077/ https://ncbi.nlm.nih.gov/pubmed/24561254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.030 |
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