Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10

Some recombinant adeno-associated viruses (rAAVs) can cross the neonatal blood–brain barrier (BBB) and efficiently transduce cells of the central nervous system (CNS). However, in the adult CNS, transduction levels by systemically delivered rAAVs are significantly reduced, limiting their potential f...

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Detalhes bibliográficos
Main Authors: Yang, Bin, Li, Shaoyong, Wang, Hongyan, Guo, Yansu, Gessler, Dominic J, Cao, Chunyan, Su, Qin, Kramer, Joshua, Zhong, Li, Ahmed, Seemin Seher, Zhang, Hongwei, He, Ran, Desrosiers, Ronald C, Brown, Robert, Xu, Zuoshang, Gao, Guangping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089005/
https://ncbi.nlm.nih.gov/pubmed/24781136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.68
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