Slow intrathecal injection of rAAVrh10 enhances its transduction of spinal cord and therapeutic efficacy in a mutant SOD1 model of ALS

Mutant SOD1 causes amyotrophic lateral sclerosis (ALS) by a dominant gain of toxicity. Previous studies have demonstrated therapeutic potential of mutant SOD1-RNAi delivered by intrathecal (IT) injection of recombinant adeno-associated virus (rAAV). However, optimization of delivery is needed to ove...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Neuroscience
Auteurs principaux: Li, Dongxiao, Liu, Chong, Yang, Chunxing, Wang, Dan, Wu, Dongxia, Qi, Yinkuang, Su, Qin, Gao, Guangping, Xu, Zuoshang, Guo, Yansu
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757625/
https://ncbi.nlm.nih.gov/pubmed/29024785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2017.10.001
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires