Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits

Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a poly-glutamine (poly-Q) stretch in the huntingtin (Htt) protein. Gain-of-function effects of mutant Htt have been extensively investigated as the major driver of neurodegeneration in HD. However, loss-of-funct...

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Main Authors: McKinstry, Spencer U., Karadeniz, Yonca B., Worthington, Atesh K., Hayrapetyan, Volodya Y., Ozlu, M. Ilcim, Serafin-Molina, Karol, Risher, W. Christopher, Ustunkaya, Tuna, Dragatsis, Ioannis, Zeitlin, Scott, Yin, Henry H., Eroglu, Cagla
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4087216/
https://ncbi.nlm.nih.gov/pubmed/25009276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4699-13.2014
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