Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival

Huntington’s disease (HD) is caused by an autosomal dominant polyglutamine expansion mutation of Huntingtin (HTT). HD patients suffer from progressive motor, cognitive, and psychiatric impairments, along with significant degeneration of the striatal projection neurons (SPNs) of the striatum. HD is w...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Burrus, Caley J., McKinstry, Spencer U., Kim, Namsoo, Ozlu, M. Ilcim, Santoki, Aditya V., Fang, Francia Y., Ma, Annie, Karadeniz, Yonca B., Worthington, Atesh K., Dragatsis, Ioannis, Zeitlin, Scott, Yin, Henry H., Eroglu, Cagla
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7025500/
https://ncbi.nlm.nih.gov/pubmed/31968243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.12.069
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