Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts

BACKGROUND: The polyglutamine expansion in huntingtin (Htt) protein is a cause of Huntington's disease (HD). Htt is an essential gene as deletion of the mouse Htt gene homolog (Hdh) is embryonic lethal in mice. Therefore, in addition to elucidating the mechanisms responsible for polyQ-mediated...

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Main Authors: Zhang, Hua, Das, Sudipto, Li, Quan-Zhen, Dragatsis, Ioannis, Repa, Joyce, Zeitlin, Scott, Hajnóczky, György, Bezprozvanny, Ilya
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377268/
https://ncbi.nlm.nih.gov/pubmed/18412970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-38
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