Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis

Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of the WNT pathway that is responsible for APC-associated diseases such as Familial Adenomatous Polyposis (FAP) and 85% of spontaneous colorectal cancers (CRC). FAP is characterized by multiple intest...

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Bibliografiske detaljer
Main Authors: Li, Bin, Flaveny, Colin A., Giambelli, Camilla, Fei, Dennis Liang, Han, Lu, Hang, Brian I., Bai, Feng, Pei, Xin-Hai, Nose, Vania, Burlingame, Oname, Capobianco, Anthony J., Orton, Darren, Lee, Ethan, Robbins, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086981/
https://ncbi.nlm.nih.gov/pubmed/25003333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101969
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