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Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells

Azide-enabled adenovirus for gene delivery: We demonstrate here a novel two-step “click” labeling process in which adenoviral particles are first metabolically labeled during production with unnatural azido sugars. Subsequent chemoselective modification allows access to viruses decorated with a broa...

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Main Authors: Banerjee, Partha Sarathi, Ostapachuk, Philomena, Hearing, Patrick, Carrico, Isaac
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086407/
https://ncbi.nlm.nih.gov/pubmed/20831164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja104547x
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