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Unnatural Amino Acid Incorporation onto Adenoviral (Ad) Coat Proteins Facilitates Chemoselective Modification and Retargeting of Ad Type 5 Vectors

Surface modification of adenovirus vectors can improve tissue-selective targeting, attenuate immunogenicity, and enable imaging of particle biodistribution, thus significantly improving therapeutic potential. Currently, surface engineering is constrained by a combination of factors, including impact...

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Autori principali: Banerjee, Partha Sarathi, Ostapchuk, Philomena, Hearing, Patrick, Carrico, Isaac Sheridan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147895/
https://ncbi.nlm.nih.gov/pubmed/21613404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00118-11
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