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Atorvastatin prevents amyloid-β peptide oligomer-induced synaptotoxicity and memory dysfunction in rats through a p38 MAPK-dependent pathway
AIM: To investigate whether atorvastatin treatment could prevent Aβ(1-42) oligomer (AβO)-induced synaptotoxicity and memory dysfunction in rats, and to elucidate the mechanisms involved in the neuroprotective actions of atorvastatin. METHODS: SD rats were injected with AβOs (5 nmol, icv). The rats w...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086387/ https://ncbi.nlm.nih.gov/pubmed/24793311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.203 |
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