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Atorvastatin prevents Aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting Tau cleavage

AIM: The proteolytic cleavage of Tau is involved in Aβ-induced neuronal dysfunction and cell death. In this study, we investigated whether atorvastatin could prevent Tau cleavage and hence prevent Aβ(1–42) oligomer (AβO)-induced neurotoxicity in cultured cortical neurons. METHODS: Cultured rat hippo...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Sui, Hai-juan, Zhang, Ling-ling, Liu, Zhou, Jin, Ying
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422942/
https://ncbi.nlm.nih.gov/pubmed/25891085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.161
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