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Atorvastatin prevents Aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting Tau cleavage
AIM: The proteolytic cleavage of Tau is involved in Aβ-induced neuronal dysfunction and cell death. In this study, we investigated whether atorvastatin could prevent Tau cleavage and hence prevent Aβ(1–42) oligomer (AβO)-induced neurotoxicity in cultured cortical neurons. METHODS: Cultured rat hippo...
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| Publicado no: | Acta Pharmacol Sin |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4422942/ https://ncbi.nlm.nih.gov/pubmed/25891085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.161 |
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