Inhibition of Choline Acetyltransferase as a Mechanism for Cholinergic Dysfunction Induced by Amyloid-β Peptide Oligomers

Dysregulated cholinergic signaling is an early hallmark of Alzheimer disease (AD), usually ascribed to degeneration of cholinergic neurons induced by the amyloid-β peptide (Aβ). It is now generally accepted that neuronal dysfunction and memory deficits in the early stages of AD are caused by the neu...

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Main Authors: Nunes-Tavares, Nilson, Santos, Luís Eduardo, Stutz, Bernardo, Brito-Moreira, Jordano, Klein, William L., Ferreira, Sérgio T., de Mello, Fernando G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365976/
https://ncbi.nlm.nih.gov/pubmed/22505713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.321448
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