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Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis
When human fibroblasts take up plasma low density lipoprotein (LDL), its cholesterol is liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it inhibits cholesterol synthesis by blocking activation of SREBPs. This feedback protects against cholesterol overaccumulation i...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086274/ https://ncbi.nlm.nih.gov/pubmed/24920391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02882 |
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