Activation of the Stimulator of Interferon Genes (STING) adaptor attenuates experimental autoimmune encephalitis

Cytosolic DNA sensing activates the Stimulator of Interferon Genes (STING) adaptor to induce interferon type I (IFNαβ) production. Constitutive DNA sensing to induce sustained STING activation incites tolerance breakdown leading to autoimmunity. Here we show that systemic treatments with DNA nanopar...

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Hlavní autoři: Lemos, Henrique, Huang, Lei, Chandler, Phillip R., Mohamed, Eslam, Souza, Guilherme R., Li, Lingqian, Pacholczyk, Gabriela, Barber, Glen N., Hayakawa, Yoshihiro, Munn, David H., Mellor, Andrew L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086255/
https://ncbi.nlm.nih.gov/pubmed/24799564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303258
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