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Off-target effect of doublecortin-family shRNA on neuronal migration associated with endogenous microRNA dysregulation
Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function, however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086250/ https://ncbi.nlm.nih.gov/pubmed/24945770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.04.036 |
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