ARRY-334543 reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2

BACKGROUND: ARRY-334543 is a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases. We conducted this study to determine whether ARRY-334543 can enhance the efficacy of conventional anticancer drugs through interaction with ABC transporters. METHODS: Lung cancer cell line NCI-H460 and its ABC...

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Autors principals: Wang, De-Shen, Patel, Atish, Sim, Hong-May, Zhang, Yun-Kai, Wang, Yi-Jun, Kathawala, Rishil J., Zhang, Hui, Talele, Tanaji T., Ambudkar, Suresh V., Xu, Rui-Hua, Chen, Zhe-Sheng
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086246/
https://ncbi.nlm.nih.gov/pubmed/24939447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24787
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