Accurate phosphoregulation of kinetochore–microtubule affinity requires unconstrained molecular interactions

Accurate chromosome segregation relies on dynamic interactions between microtubules (MTs) and the NDC80 complex, a major kinetochore MT-binding component. Phosphorylation at multiple residues of its Hec1 subunit may tune kinetochore–MT binding affinity for diverse mitotic functions, but molecular de...

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Hauptverfasser: Zaytsev, Anatoly V., Sundin, Lynsie J.R., DeLuca, Keith F., Grishchuk, Ekaterina L., DeLuca, Jennifer G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085703/
https://ncbi.nlm.nih.gov/pubmed/24982430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201312107
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