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Basic mechanism for biorientation of mitotic chromosomes is provided by the kinetochore geometry and indiscriminate turnover of kinetochore microtubules

Accuracy of chromosome segregation relies on the ill-understood ability of mitotic kinetochores to biorient, whereupon each sister kinetochore forms microtubule (MT) attachments to only one spindle pole. Because initial MT attachments result from chance encounters with the kinetochores, biorientatio...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Zaytsev, Anatoly V., Grishchuk, Ekaterina L.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710231/
https://ncbi.nlm.nih.gov/pubmed/26424798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-06-0384
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