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Molecular determinants of ligand binding at the human histamine H(1) receptor: Site-directed mutagenesis results analyzed with ligand docking and molecular dynamics studies at H(1) homology and crystal structure models
The human histamine H(1) G-protein coupled receptor (GPCR) is an important drug target for inflammatory, sleep, and other neuropsychiatric disorders. To delineate molecular determinants for ligand binding for drug discovery purposes, human H(1) receptor models were built by homology to the crystal s...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4085681/ https://ncbi.nlm.nih.gov/pubmed/25013351 |
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