Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy

Multiple mutations in cardiac troponin T (cTnT) can cause familial hypertrophic cardiomyopathy (FHC). Patients with cTnT mutations generally exhibit mild or no ventricular hypertrophy, yet demonstrate a high frequency of early sudden death. To understand the functional basis of these phenotypes, we...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Tardiff, Jil C., Hewett, Timothy E., Palmer, Bradley M., Olsson, Charlotte, Factor, Stephen M., Moore, Russell L., Robbins, Jeffrey, Leinwand, Leslie A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 1999
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408522/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10449439/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6067
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