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Detecting Signals in Pharmacogenomic Genome-Wide Association Studies

In one common pharmacogenomic scenario, outcome measures are compared for treated and untreated subjects across genotype defined subgroups. The key question is whether treatment benefit (or harm) is particularly strong in certain subgroups, and therefore statistical analysis focuses on the interacti...

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Hlavní autoři: Wakefield, Jon, Skrivankova, Veronika, Hsu, Fang-Chi, Sale, Michele, Heagerty, Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085158/
https://ncbi.nlm.nih.gov/pubmed/24394200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2013.44
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