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The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

Recent data point to the contribution of P-glycoprotein (P-gp) to digoxin elimination. On the basis of clinical observations of patients in whom digoxin levels decreased considerably when treated with rifampin, we hypothesized that concomitant rifampin therapy may affect digoxin disposition in human...

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Autors principals: Greiner, Bernd, Eichelbaum, Michel, Fritz, Peter, Kreichgauer, Hans-Peter, von Richter, Oliver, Zundler, Johannes, Kroemer, Heyo K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC408477/
https://ncbi.nlm.nih.gov/pubmed/10411543
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