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Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells
BACKGROUND AND PURPOSE: Oral drug bioavailability is limited by intestinal expression of P-glycoprotein (MDR1, Pgp, ABCB1) whose capacity is regulated via nuclear receptors e.g. the pregnane X receptor (PXR, SXR, NR1I2). In order to study dynamic regulation of MDR1 transport capacity we have identif...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2438975/ https://ncbi.nlm.nih.gov/pubmed/18332862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.69 |
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