Association study of the let-7 miRNA-complementary site variant in the 3’ untranslated region of the KRAS gene in stage III colon cancer (NCCTG N0147 clinical trial)

PURPOSE: A let-7 microRNA-complementary site (LCS6) polymorphism in the 3’UTR of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression. We evaluated the LCS6 genotype and its association with KRAS mutation status, clinicopathological features, and disease-free survival...

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Hlavní autoři: Sha, Dan, Lee, Adam, Shi, Qian, Alberts, Steven R., Sargent, Daniel J., Sinicrope, Frank A., Diasio, Robert B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084689/
https://ncbi.nlm.nih.gov/pubmed/24727325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0069
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