Anti-miRs Competitively Inhibit microRNAs in Argonaute Complexes

MicroRNAs (miRNAs), small RNA molecules that post-transcriptionally regulate mRNA expression, are crucial in diverse developmental and physiological programs and their misregulation can lead to disease. Chemically modified oligonucleotides have been developed to modulate miRNA activity for therapeut...

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Main Authors: Hogan, Daniel J., Vincent, Thomas M., Fish, Sarah, Marcusson, Eric G., Bhat, Balkrishen, Chau, B. Nelson, Zisoulis, Dimitrios G.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084633/
https://ncbi.nlm.nih.gov/pubmed/24992387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100951
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