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Multiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channel

The influenza A virus M2 channel (AM2) is crucial in the viral life cycle. Despite many previous experimental and computational studies, the mechanism of the activating process in which proton permeation acidifies the virion to release the viral RNA and core proteins is not well understood. Herein t...

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Detalles Bibliográficos
Main Authors: Liang, Ruibin, Li, Hui, Swanson, Jessica M. J., Voth, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084430/
https://ncbi.nlm.nih.gov/pubmed/24979779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401997111
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