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Substitution of transmembrane domain Cys residues alters pH(o)-sensitive anion transport by AE2/SLC4A2 anion exchanger
AE2/SLC4A2 is the most widely expressed of the Na(+)-independent SLC4 Cl(−)/HCO (−)(3) exchangers and is essential for postnatal survival, but its structure remains unknown. We have generated and expressed a mouse AE2 construct devoid of transmembrane domain cysteine (Cys) residues, mAE2(Cys-less),...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4083511/ https://ncbi.nlm.nih.gov/pubmed/23271450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-012-1196-6 |
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