Inhibition of Notch Signaling in Combination with Paclitaxel Reduces Platinum-Resistant Ovarian Tumor Growth

Introduction: Ovarian cancer (OvCa) is the most lethal gynecologic malignancy in the United States because of chemoresistant recurrent disease. Our objective was to investigate the efficacy of inhibiting the Notch pathway with a γ-secretase inhibitor (GSI) in an OvCa patient-derived xenograft model...

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Autors principals: Groeneweg, Jolijn W., DiGloria, Celeste M., Yuan, Jing, Richardson, William S., Growdon, Whitfield B., Sathyanarayanan, Sriram, Foster, Rosemary, Rueda, Bo R.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083224/
https://ncbi.nlm.nih.gov/pubmed/25072022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00171
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