All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis

The current study investigates the cellular events which trigger activation of proapoptotic Bcl-2-associated X protein (Bax) in retinal cell death induced by all-trans-retinal (atRAL). Cellular events which activate Bax, such as DNA damage by oxidative stress and phosphorylation of p53, were evaluat...

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Bibliografiske detaljer
Main Authors: Sawada, Osamu, Perusek, Lindsay, Kohno, Hideo, Howell, Scott J., Maeda, Akiko, Matsuyama, Shigemi, Maeda, Tadao
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083191/
https://ncbi.nlm.nih.gov/pubmed/24726920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2014.04.003
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