Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer

BACKGROUND: Genetic predisposition is the primary risk factor for familial breast cancer. For the majority of familial breast cancer, however, the genetic predispositions remain unknown. All newly identified predispositions occur rarely in disease population, and the unknown genetic predispositions...

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Autores principales: Wen, Hongxiu, Kim, Yeong C, Snyder, Carrie, Xiao, Fengxia, Fleissner, Elizabeth A, Becirovic, Dina, Luo, Jiangtao, Downs, Bradley, Sherman, Simon, Cowan, Kenneth H, Lynch, Henry T, Wang, San Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083142/
https://ncbi.nlm.nih.gov/pubmed/24969172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-470
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