Differences of Variable Number Tandem Repeats in XRCC5 Promoter Are Associated with Increased or Decreased Risk of Breast Cancer in BRCA Gene Mutation Carriers

Ku80 is a subunit of the Ku heterodimer that binds to DNA double-strand break ends as part of the non-homologous end joining (NHEJ) pathway. Ku80 is also involved in homologous recombination (HR) via its interaction with BRCA1. Ku80 is encoded by the XRCC5 gene that contains a variable number tandem...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Cui, Jian, Luo, Jiangtao, Kim, Yeong C., Snyder, Carrie, Becirovic, Dina, Downs, Bradley, Lynch, Henry, Wang, San Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829605/
https://ncbi.nlm.nih.gov/pubmed/27148484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2016.00092
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