Analysis of single-nucleotide polymorphisms (SNPs) in human CYP3A4 and CYP3A5 genes: potential implications for the metabolism of HIV drugs

BACKGROUND: Drug metabolism via the cytochrome P450 (CYP450) system has emerged as an important determinant in the occurrence of several drug interactions (adverse drug reactions, reduced pharmacological effect, drug toxicities). In particular, CYP3A4 and CYP3A5 (interacting with more than 60% of li...

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Detaylı Bibliyografya
Asıl Yazarlar: Berno, Giulia, Zaccarelli, Mauro, Gori, Caterina, Tempestilli, Massimo, Antinori, Andrea, Perno, Carlo Federico, Pucillo, Leopoldo Paolo, D’Arrigo, Roberta
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2014
Konular:
Technical Advance
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083125/
https://ncbi.nlm.nih.gov/pubmed/24986243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-15-76
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