Analysis of single-nucleotide polymorphisms (SNPs) in human CYP3A4 and CYP3A5 genes: potential implications for the metabolism of HIV drugs

BACKGROUND: Drug metabolism via the cytochrome P450 (CYP450) system has emerged as an important determinant in the occurrence of several drug interactions (adverse drug reactions, reduced pharmacological effect, drug toxicities). In particular, CYP3A4 and CYP3A5 (interacting with more than 60% of li...

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Hlavní autoři: Berno, Giulia, Zaccarelli, Mauro, Gori, Caterina, Tempestilli, Massimo, Antinori, Andrea, Perno, Carlo Federico, Pucillo, Leopoldo Paolo, D’Arrigo, Roberta
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Technical Advance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083125/
https://ncbi.nlm.nih.gov/pubmed/24986243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-15-76
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