Analysis of single-nucleotide polymorphisms (SNPs) in human CYP3A4 and CYP3A5 genes: potential implications for the metabolism of HIV drugs

BACKGROUND: Drug metabolism via the cytochrome P450 (CYP450) system has emerged as an important determinant in the occurrence of several drug interactions (adverse drug reactions, reduced pharmacological effect, drug toxicities). In particular, CYP3A4 and CYP3A5 (interacting with more than 60% of li...

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Main Authors: Berno, Giulia, Zaccarelli, Mauro, Gori, Caterina, Tempestilli, Massimo, Antinori, Andrea, Perno, Carlo Federico, Pucillo, Leopoldo Paolo, D’Arrigo, Roberta
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Technical Advance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083125/
https://ncbi.nlm.nih.gov/pubmed/24986243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-15-76
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