Analysis of single-nucleotide polymorphisms (SNPs) in human CYP3A4 and CYP3A5 genes: potential implications for the metabolism of HIV drugs

BACKGROUND: Drug metabolism via the cytochrome P450 (CYP450) system has emerged as an important determinant in the occurrence of several drug interactions (adverse drug reactions, reduced pharmacological effect, drug toxicities). In particular, CYP3A4 and CYP3A5 (interacting with more than 60% of li...

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Autori principali: Berno, Giulia, Zaccarelli, Mauro, Gori, Caterina, Tempestilli, Massimo, Antinori, Andrea, Perno, Carlo Federico, Pucillo, Leopoldo Paolo, D’Arrigo, Roberta
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Technical Advance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083125/
https://ncbi.nlm.nih.gov/pubmed/24986243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-15-76
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