Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing

Genome editing has attracted wide interest for the generation of cellular models of disease using human pluripotent stem cells and other cell types. CRISPR-Cas systems and TALENs can target desired genomic sites with high efficiency in human cells, but recent publications have led to concern about t...

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Main Authors: Veres, Adrian, Gosis, Bridget S., Ding, Qiurong, Collins, Ryan, Ragavendran, Ashok, Brand, Harrison, Erdin, Serkan, Talkowski, Michael E., Musunuru, Kiran
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082799/
https://ncbi.nlm.nih.gov/pubmed/24996167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.04.020
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