Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature and genotoxicity threshold

In experimental animals and humans, aflatoxin B(1) (AFB(1)) is a potent hepatic toxin and carcinogen. The synthetic oleanane triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im), a powerful activator of Keap1-Nrf2 signaling, protects against AFB(1)-induced toxicity and p...

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Bibliografiske detaljer
Main Authors: Johnson, Natalie M., Egner, Patricia A., Baxter, Victoria K., Sporn, Michael B., Wible, Ryan S., Sutter, Thomas R., Groopman, John D., Kensler, Thomas W., Roebuck, Bill D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082474/
https://ncbi.nlm.nih.gov/pubmed/24662598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-13-0430
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