Transgenic Expression of Aflatoxin Aldehyde Reductase (AKR7A1) Modulates Aflatoxin B(1) Metabolism but not Hepatic Carcinogenesis in the Rat

In both experimental animals and humans, aflatoxin B(1) (AFB(1)) is a potent hepatic toxin and carcinogen against which a variety of antioxidants and experimental or therapeutic drugs (e.g., oltipraz, related dithiolethiones, and various triterpenoids) protect from both acute toxicity and carcinogen...

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Detalhes bibliográficos
Main Authors: Roebuck, Bill D., Johnson, Denise N., Sutter, Carrie Hayes, Egner, Patricia A., Scholl, Peter F., Friesen, Marlin D., Baumgartner, Karen J., Ware, Nicholas M., Bodreddigari, Sridevi, Groopman, John D., Kensler, Thomas W., Sutter, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Carcinogenicity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675636/
https://ncbi.nlm.nih.gov/pubmed/19168568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp003
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