Transgenic Expression of Aflatoxin Aldehyde Reductase (AKR7A1) Modulates Aflatoxin B(1) Metabolism but not Hepatic Carcinogenesis in the Rat

In both experimental animals and humans, aflatoxin B(1) (AFB(1)) is a potent hepatic toxin and carcinogen against which a variety of antioxidants and experimental or therapeutic drugs (e.g., oltipraz, related dithiolethiones, and various triterpenoids) protect from both acute toxicity and carcinogen...

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Autores principales: Roebuck, Bill D., Johnson, Denise N., Sutter, Carrie Hayes, Egner, Patricia A., Scholl, Peter F., Friesen, Marlin D., Baumgartner, Karen J., Ware, Nicholas M., Bodreddigari, Sridevi, Groopman, John D., Kensler, Thomas W., Sutter, Thomas R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
Carcinogenicity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675636/
https://ncbi.nlm.nih.gov/pubmed/19168568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp003
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