Protection Against Aflatoxin B(1)-induced Cytotoxicity by Expression of the Cloned Aflatoxin B(1)-aldehyde Reductases Rat AKR7A1 and Human AKR7A3

The reduction of the aflatoxin B(1) (AFB(1)) dialdehyde metabolite to its corresponding mono and dialcohols, catalyzed by aflatoxin B(1)-aldehyde reductase (AFAR; rat AKR7A1 and human AKR7A3), is greatly increased in livers of rats treated with numerous chemoprotective agents. Recombinant human AKR7...

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Main Authors: Bodreddigari, Sridevi, Jones, Laundette Knight, Egner, Patricia A., Groopman, John D., Sutter, Carrie Hayes, Roebuck, Bill D., Guengerich, F. Peter, Kensler, Thomas W., Sutter, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838790/
https://ncbi.nlm.nih.gov/pubmed/18416522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx7004458
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