Genetic or Pharmacologic Activation of Nrf2 Signaling Fails to Protect Against Aflatoxin Genotoxicity in Hypersensitive GSTA3 Knockout Mice

Mice are resistant to aflatoxin hepatotoxicity, primarily due to high expression of glutathione S-transferases (GSTs), and in particular the GSTA3 subunit. Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling, which controls a broad-based cytoprotective response, was activated either genetic...

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Detalhes bibliográficos
Main Authors: Kensler, Kevin H., Slocum, Stephen L., Chartoumpekis, Dionysios V., Dolan, Patrick M., Johnson, Natalie M., Ilic, Zoran, Crawford, Dana R., Sell, Stewart, Groopman, John D., Kensler, Thomas W., Egner, Patricia A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Biotransformation and Toxicokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064015/
https://ncbi.nlm.nih.gov/pubmed/24675090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu056
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