The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.
p53 accumulates after DNA damage and arrests cellular growth. These findings suggest a possible role for p53 in the cellular response to DNA damage. We have previously shown that the C terminus of p53 binds DNA nonspecifically and assembles stable tetramers. In this study, we have utilized purified...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1995
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40820/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568153/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.21.9455 |
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