FABP3 Protein Promotes α-Synuclein Oligomerization Associated with 1-Methyl-1,2,3,6-tetrahydropiridine-induced Neurotoxicity

α-Synuclein (αSyn) accumulation in dopaminergic (DA) neurons is partly regulated by long-chain polyunsaturated fatty acids. We found that fatty acid-binding protein 3 (FABP3, H-FABP), a factor critical for arachidonic acid (AA) transport and metabolism in brain, is highly expressed in DA neurons. Fa...

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Autori principali: Shioda, Norifumi, Yabuki, Yasushi, Kobayashi, Yuka, Onozato, Misaki, Owada, Yuji, Fukunaga, Kohji
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081935/
https://ncbi.nlm.nih.gov/pubmed/24855640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527341
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